Ozempic and Other GLP-1 Drugs May Help Reduce Heart Attack Risk


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New analysis finds that GLP-1 drugs used to deal with kind 2 diabetes might assist scale back your threat of getting a serious cardiovascular occasion comparable to coronary heart assault, coronary heart failure, and stroke by 20%. thianchai sitthikongsak/Getty Images
  • New analysis has proven that GLP-1 medicine used for the therapy of kind 2 diabetes are related to fewer adversarial coronary heart well being occasions.
  • The examine discovered GLP-1s have been related to a 20% lowered threat of main cardiovascular occasions in older adults when in comparison with different diabetes medicine.
  • Experts say these drugs might decrease the chance of adversarial coronary heart well being due to their results on weight reduction, blood stress, and lipid profiles.
  • They additionally comprise anti-inflammatory and anti-atherosclerotic properties.

If you might have kind 2 diabetes you’re in all probability conscious that the situation places you at an elevated threat of creating coronary heart illness.

Now, a brand new examine has proven {that a} class of diabetes drugs is related to fewer main adversarial cardiovascular occasions.

The examine, performed at Vanderbilt University Medical Center, discovered that GLP-1 medicine like Ozempic (semaglutide) resulted in decrease situations of Major cardiovascular occasions (MACE) than DPP4 inhibitors (one other kind of diabetes drug) in older veterans with no prior coronary heart illness.

The use of a GLP-1 receptor agonist was related to a 20% lowered threat of MACE and coronary heart failure hospitalization when in comparison with therapy with DPP4 inhibitors, which have been considered impartial in respect to cardiac occasions.

In different phrases, these outcomes translate to roughly three fewer coronary heart failure, coronary heart assault, or stroke occasions per 1,000 individuals utilizing a GLP-1 medicine for a yr.

The examine’s researchers say these findings will assist clinicians in selecting a diabetes drug routine for older sufferers.

Christianne Roumie, MD, MPH, professor of Medicine within the Division of General Internal Medicine and Public Health and senior writer of the examine, describes it as “an important contribution to patient care” and says it “adds to what we as clinicians know about treating diabetes and heart disease prevention.”

“GLP-1 inhibitors have emerged as a promising treatment option for individuals with type 2 diabetes, demonstrating not only effective blood sugar control but also additional benefits like weight loss and reduced risk of cardiovascular disease,” says Bari Stricoff, a registered dietitian at Well Easy.

According to Stricoff, the explanation somebody with kind 2 diabetes may expertise a lowered threat of heart problems when taking a GLP-1 drug in comparison with a DPP4 inhibitor hinges on the consequences these medicine have on cardiovascular threat components.

“GLP-1 receptor agonists not only lower blood sugar levels but also have additional cardiovascular benefits,” she factors out.

“Firstly, obesity is a major risk factor for cardiovascular disease, and GLP-1 receptor agonists can promote weight loss by reducing appetite and increasing satiety,” Stricoff explains. “Secondly, some GLP-1 drugs have been shown to reduce blood pressure, which is an important cardiovascular risk factor.”

Additionally, Stricoff says some research recommend GLP-1s have anti-inflammatory and anti-atherosclerotic results, each of which might scale back the chance of heart problems.

“GLP-1 medications can also have a positive effect on lipid profiles, such as reducing triglyceride levels, which may contribute to a reduced risk of cardiovascular events,” Stricoff provides.

Similarly, Crystal Scott, a registered dietitian at Top Nutrition Coaching, says the outcomes of this examine are according to earlier proof on the hyperlinks between GLP-1 medicine and cardiovascular well being in individuals with kind 2 diabetes.

Like Stricoff, she factors to the cardioprotective results of GLP-1s, noting how these medicine can improve endothelial operate, scale back arterial stiffness, and reduce irritation, all of which might contribute to the event and development of heart problems.

“It’s important to note that the study was retrospective and observational, so it cannot establish causality or rule out potential confounding factors,” she factors out.

“Future randomized controlled trials are needed to confirm these findings and to determine how these medications can be used optimally to prevent cardiovascular disease in people with type 2 diabetes,” she surmises.

Additionally, Scott notes that the examine inhabitants consisted of U.S. veterans, so the outcomes is probably not generalizable to different populations.

Furthermore, the examine didn’t study the long-term security and efficacy of those drugs, she factors out.

While the hyperlinks between GLP-1 medicine and lowered threat of adversarial coronary heart well being are promising, Stricoff says, it’s essential to acknowledge that these drugs primarily deal with the signs and penalties of kind 2 diabetes fairly than the basis causes of the illness.

“While GLP-1 inhibitors can be life-changing for some patients, they should be considered as part of a comprehensive treatment plan that includes nutrition education and behavioral interventions to promote long-term health and wellness,” she surmises.

So, GLP-1s apart, what else are you able to do to enhance your coronary heart well being?

Stricoff says life-style components play an essential position.

“Unhealthy lifestyle choices, such as a poor diet, physical inactivity, and smoking, are common risk factors for both type 2 diabetes and heart disease, and these factors can exacerbate the risk of developing heart disease in people with diabetes,” she explains.

What’s extra, she says it’s essential to pair GLP-1 inhibitor remedy with interventions that concentrate on the basis causes of kind 2 diabetes and promote long-term habits change.

“Nutrition education is a vital component of this approach, as it empowers patients to make informed decisions about their food choices, understand the impact of diet on their health, and adopt healthier eating habits that can be sustained even in the absence of medication,” she surmises.

Specifically, Scott advises following a food plan that’s low in saturated and trans fat, sodium, and added sugars, and excessive in fiber, complete grains, fruits, and greens.

She additionally recommends participating in common bodily exercise, comparable to brisk strolling, biking, swimming, or dancing, for a minimum of 150 minutes per week.

Medications usually include an extended checklist of scary unintended effects, so it’s actually promising that GLP-1 medicine are linked with a decrease threat of adversarial cardiac occasions. The outcomes of this examine might assist your clinician select an applicable therapy for you.

However, efficient as these medicine could also be, each specialists agree, you shouldn’t neglect the fundamentals: eat nicely, transfer extra, and give up smoking.



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